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1

Synthesis and derivatization of novel 4-aroylthiophene-and furan-2-sulfonamides

George D. Hartman, Wasyl Halczenko

Journal:

Journal of Heterocyclic Chemistry

Year:

1989

File:

PDF, 427 KB

1989

2

Disposition of a novel and potent α v β 3 antagonist in animals, and extrapolation to man

Prueksaritanont, T., Fernandez-Metzler, C., Meng, Y., Barrish, A., Halczenko, W., Rodan, S. B., Hutchinson, J. H., Duggan, M. E., Lin, J. H.

Journal:

Year:

2004

Language:

english

File:

PDF, 188 KB

english, 2004

3

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives

Duggan, Mark E., Alberts, Alfred W., Bostedor, Rick, Chao, Yu Sheng, Germershausen, John I., Gilfillan, James L., Halczenko, Wasyl, Hartman, George D., Hunt, Vincent

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 997 KB

english, 1991

4

Benzocycloheptapyridines. Analogs of azatadine

Wasyl Halczenko, Kenneth L. Shepard

Journal:

Journal of Heterocyclic Chemistry

Year:

1986

Language:

english

File:

PDF, 671 KB

english, 1986

5

Tirofiban (Aggrastat®)

Jacquelynn J. Cook, Bohumil Bednar, Joseph J. Lynch Jr., Robert J. Gould, Melissa S. Egbertson, Wasyl Halczenko, Mark E. Duggan, George D. Hartman, Man-Wai Lo, Gail M. Murphy, Lawrence I. Deckelbaum,

Journal:

Cardiovascular Therapeutics

Year:

1999

Language:

english

File:

PDF, 344 KB

english, 1999

6

Imino-Bridged heterocycles. V . Synthesis of 6,11-dimethyl-1 1H-benzo[5,6]cyclohepta[1,2-c]pyridin-6,11-imine by a regiospecific amide to olefin cyclization

Daniel G. Brenner, Wasyl Halczenko, Kenneth L. Shepard

Journal:

Journal of Heterocyclic Chemistry

Year:

1986

Language:

english

File:

PDF, 319 KB

english, 1986

7

Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors

Hartman, George D., Halczenko, Wasyl, Prugh, John D., Smith, Robert L., Sugrue, Michael F., Mallorga, Pierre, Michelson, Stuart R., Randall, William C., Schwam, Harvey, Sondey, John M.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 961 KB

english, 1992

8

ChemInform Abstract: Synthesis and Derivatization of 4-Arylsulfonylthiophene- and -furan-2-sulfonamides.

HARTMAN, G. D., HALCZENKO, W.

Journal:

Year:

1990

File:

PDF, 185 KB

1990

9

ChemInform Abstract: Iminium Ion-Mediated Cyclizations of 4-Aryl-1,4-dihydropyridines. Regio- and Stereoselective Intermolecular Cycloaddition Reactions.

HARTMAN, G. D., PHILLIPS, B. T., HALCZENKO, W., PITZENBERGER, S. M.

Journal:

Year:

1990

File:

PDF, 149 KB

1990

10

ChemInform Abstract: AKTIVIERTE 3,5-DIAMINO-6-CHLOR-PYRAZIN-CARBONSAEUREESTER UND IHRE RK.

SHEPARD, K. L., HALCZENKO, W., CRAGOE, E. J.

Journal:

Chemischer Informationsdienst. Organische Chemie

Year:

1970

File:

PDF, 168 KB

1970

11

The Synthesis of 5-Alkylaminomethylthieno[2,3-b]pyrrole-5-sulfonamides

D. Hartman, George, Halczenko, Wasyl

Journal:

Year:

1989

Language:

english

File:

PDF, 179 KB

english, 1989

12

ChemInform Abstract: Iminium Ion-Mediated Cyclizations of 4-Aryl-1,4-dihydropyridines. Regio- and Stereoselectivity in Intermolecular Reactions.

HARTMAN, G. D., PHILLIPS, B. T., HALCZENKO, W., SPRINGER, J. P., HIRSHFIELD, J.

Journal:

Year:

1987

File:

PDF, 196 KB

1987

13

ChemInform Abstract: Benzocycloheptapyridines. Analogs of Azatadine.

HALCZENKO, W., SHEPARD, K. L.

Journal:

Chemischer Informationsdienst

Year:

1986

File:

PDF, 246 KB

1986

14

ChemInform Abstract: Nonpeptide Glycoprotein IIB/IIIA Inhibitors. Part 18. Indole α-Sulfonamide Acids are Potent Inhibitors of Platelet Aggregation.

K. M. BRASHEAR, J. J. COOK, B. BEDNAR, R. A. BEDNAR, R. J. GOULD, W. HALCZENKO, M. A. HOLAHAN, R. J. LYNCH, G. D. HARTMAN, J. H. HUTCHINSON

Journal:

Year:

1998

File:

PDF, 31 KB

1998

15

ChemInform Abstract: Studies Directed Towards the Regioselective Carboxylation of the 4-Oxo- 4,5,6,7-tetrahydrothieno(3,2-c)pyridine Ring System.

W. HALCZENKO, G. D. HARTMAN

Journal:

Year:

1996

File:

PDF, 30 KB

1996

16

Imino-bridged heterocycles. III . Synthesis of mono-bridgehead substituted 11H-benzo[5,6]cyclohepta[1,2-c]pyridin-6,11-imines by regiospecific amine to olefin cyclizations

Daniel G. Brenner, Wasyl Halczenko, Kenneth L. Shepard

Journal:

Journal of Heterocyclic Chemistry

Year:

1985

File:

PDF, 380 KB

1985

17

Iminium-ion-mediated cyclizations of 4-aryl-1,4-dihydropyridines. Regio- and stereoselectivity in intermolecular reactions

Hartman, George D., Phillips, Brian T., Halczenko, Wasyl, Springer, James P., Hirshfield, Jordan

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 483 KB

english, 1987

18

ChemInform Abstract: IMINO-BRIDGED HETEROCYCLES. II. (1). REGIOSPECIFIC SYNTHESIS OF THE 11H-BENZO(5,6)CYCLOHEPTA(1,2-C)PYRIDIN-6,11-IMINE AND 5H-BENZO(4,5)CYCLOHEPTA(1,2-B)PYRIDIN-5,10-IMINE SYSTEMS

BRENNER, D. G., HALCZENKO, W., SHEPARD, K. L.

Journal:

Chemischer Informationsdienst

Year:

1983

File:

PDF, 222 KB

1983

19

ChemInform Abstract: Non-Peptide Glycoprotein IIb/IIIa Antagonists. Part 11. Design and in vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs.

J. H. HUTCHINSON, J. J. COOK, K. M. BRASHEAR, M. J. BRESLIN, J. D. GLASS, R. J. GOULD, W. HALCZENKO, M. A. HOLAHAN, R. J. LYNCH, G. R. SITKO, M. T. STRANIERI, G. D. HARTMAN

Journal:

Year:

1997

File:

PDF, 33 KB

1997

20

Non-Peptide αvβ3 antagonists. Part 6: Design and synthesis of αvβ3 antagonists containing a pyridone or pyrazinone central scaffold

Michael J Breslin, Mark E Duggan, Wasyl Halczenko, Carmen Fernandez-Metzler, Cecilia A Hunt, Chih-Tai Leu, Kara M Merkle, Adel M Naylor-Olsen, Thomayant Prueksaritanont, Gary Stump, Audrey Wallace, Se

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 192 KB

english, 2003

21

ChemInform Abstract: IMINO-BRIDGED HETEROCYCLES. III. SYNTHESIS OF MONO-BRIDGEHEAD SUBSTITUTED 11H-BENZO(5,6)CYCLOHEPTA(1,2-C)PYRIDIN-6,11-IMINES BY REGIOSPECIFIC AMINE TO OLEFIN CYCLIZATIONS

BRENNER, D. G., HALCZENKO, W., SHEPARD, K. L.

Journal:

Chemischer Informationsdienst

Year:

1985

File:

PDF, 223 KB

1985

22

The preparation of 5-substituted thieno[2,3-b]furan-2-sulfonamides

George D. Hartman, Wasyl Halczenko, John D. Prugh, Theresa M. Williams

Journal:

Journal of Heterocyclic Chemistry

Year:

1990

File:

PDF, 296 KB

1990

23

ChemInform Abstract: SYNTHESIS OF 9,10-DIHYDROANTHRACEN-9,10-IMINES

ANDERSON, P. S., CHRISTY, M. E., COLTON, C. D., HALCZENKO, W., PONTICELLO, G. S., SHEPARD, K. L.

Journal:

Chemischer Informationsdienst

Year:

1979

File:

PDF, 240 KB

1979

24

Synthesis and derivatization of 4-arylsulfonylthiophene- and furan-2-sulfonamides

George D. Hartman, Wasyl Halczenko

Journal:

Journal of Heterocyclic Chemistry

Year:

1990

File:

PDF, 615 KB

1990

25

Studies Directed Toward the Regioselective Carboxylation of the 4-Oxo-4,5,6,7-Tetrahydrothieno-[3,2-C]pyridine Ring System

Halczenko, Wasyl, Hartman, George D.

Journal:

Synthetic Communications

Year:

1996

Language:

english

File:

PDF, 277 KB

english, 1996

26

ChemInform Abstract: ACTIVATED ESTERS OF SUBSTITUTED PYRAZINECARBOXYLIC ACIDS

SHEPARD, K. L., HALCZENKO, W., CRAGOE, E. J. JUN.

Journal:

Chemischer Informationsdienst

Year:

1977

File:

PDF, 216 KB

1977

27

Iminium ion-mediated cyclizations of 4-aryl-1,4-dihydropyridines. Alternate cyclization pathways

Hartman, George D., Halczenko, Wasyl, Cochran, David W.

Journal:

Canadian Journal of Chemistry

Year:

1986

Language:

english

File:

PDF, 278 KB

english, 1986

28

Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone

David B. Whitman, Ben C. Askew, Le T. Duong, Carmen Fernandez-Metzler, Wasyl Halczenko, George D. Hartman, John H. Hutchinson, Chih-Tai Leu, Thomayant Prueksaritanont, Gideon A. Rodan, Sevgi B. Rodan,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 257 KB

english, 2004

29

Regioselective generation and trapping of mono- and dianions of 3-arylsulfonyl furans. Bidentate carbanion stabilization via sulfones

George D. Hartman, Wasyl Halczenko

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 194 KB

english, 1987

30

A Convenient Synthesis of 4-Aminomethyl-L-Phenylalanine

Hartman, George D., Halczenko, Wasyl

Journal:

Synthetic Communications

Year:

1991

Language:

english

File:

PDF, 202 KB

english, 1991

31

ChemInform Abstract: AKTIVIERTE 3,5-DIAMINO-6-CHLOR-PYRAZIN-CARBONSAEUREESTER UND IHRE RK.

SHEPARD, K. L., HALCZENKO, W., CRAGOE, E. J.

Journal:

Chemischer Informationsdienst. Organische Chemie

Year:

1970

File:

PDF, 168 KB

1970

32

Nonpeptide glycoprotein IIB/IIIA inhibitors. 12. Potent and orally active centrally constrained thieno[2,3-c]pyridones

Wasyl Halczenko, Jacquelynn J. Cook, Marie A. Holahan, Gary R. Sitko, Maria T. Stranieri, Guixiang Zhang, Robert J. Lynch, Joseph J. Lynch Jr., Robert J. Gould, George D. Hartman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 254 KB

english, 1996

33

Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp

Egbertson, Melissa S., Chang, Charles T.-C., Duggan, Mark E., Gould, Robert J., Halczenko, Wasyl, Hartman, George D., Laswell, William L., Lynch, Joseph J., Lynch, Robert J.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.44 MB

english, 1994

34

Iminium ion-mediated cyclizations of 4-aryl-1,4-dihydropyridines. Regio- and stereoselective intermolecular cycloaddition reactions

Hartman, George D., Phillips, Brian T., Halczenko, Wasyl, Pitzenberger, Steven M.

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 518 KB

english, 1989

35

Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1 H )-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs

Hutchinson, John H., Cook, Jacquelynn J., Brashear, Karen M., Breslin, Michael J., Glass, Joan D., Gould, Robert J., Halczenko, Wasyl, Holahan, Marie A., Lynch, Robert J., Sitko, Gary R., Stranieri, M

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 345 KB

english, 1996

36

ChemInform Abstract: Iminium Ion Mediated Cyclizations with 4-Aryl-1,4-dihydropyridines.

HARTMAN, G. D., HALCZENKO, W., PHILLIPS, B. T.

Journal:

Chemischer Informationsdienst

Year:

1986

File:

PDF, 159 KB

1986

37

ChemInform Abstract: CARBOXYLIC N,N-DIPHENYLCARBAMIC ANHYDRIDES. NEW ACYLATING AGENTS

SHEPARD, K. L., HALCZENKO, W.

Journal:

Chemischer Informationsdienst

Year:

1979

File:

PDF, 194 KB

1979

38

4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors

Hartman, George D., Halczenko, Wasyl, Smith, Robert L., Sugrue, Michael F., Mallorga, Pierre J., Michelson, Stuart R., Randall, William C., Schwam, Harvey, Sondey, John M.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

39

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs

Hartman, George D., Halczenko, Wasyl, Duggan, Mark E., Imagire, Jill S., Smith, Robert L., Pitzenberger, Steven M., Fitzpatrick, Susan L., Alberts, Alfred W., Bostedor, Rick

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.13 MB

english, 1992

40

Iminium ion mediated cyclizations with 4-aryl-1,4-dihydropyridines. Bridging with thiophene and furan

Hartman, George D., Halczenko, Wasyl, Phillips, Brian T.

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 899 KB

english, 1986

41

ChemInform Abstract: Imino-Bridged Heterocycles. Part 5. Synthesis of 6,11-Dimethyl-11H-benzo[5,6]cyclohepta[1,2-c]pyridin-6,11-imine by a Regiospecific Amide to Olefin Cyclization.

BRENNER, D. G., HALCZENKO, W., SHEPARD, K. L.

Journal:

Chemischer Informationsdienst

Year:

1986

File:

PDF, 145 KB

1986

42

ChemInform Abstract: α-ADRENERGIC ACTIVITIES OF SOME SUBSTITUTED 2-(AMINOMETHYL)IMIDAZOLINES

SAARI, W. S., HALCZENKO, W., RANDALL, W. C., LOTTI, V. J.

Journal:

Chemischer Informationsdienst

Year:

1984

File:

PDF, 112 KB

1984

43

.alpha.-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines

Saari, Walfred S., Halczenko, Wasyl, Randall, William C., Lotti, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 434 KB

english, 1983

44

ChemInform Abstract: Synthesis and Derivatization of Novel 4-Aroylthiophene- and -furan-2-sulfonamides.

HARTMAN, G. D., HALCZENKO, W.

Journal:

Year:

1990

File:

PDF, 159 KB

1990

45

ChemInform Abstract: PYRIDINYLPIPERAZINES, A NEW CLASS OF SELECTIVE α2-ADRENOCEPTOR ANTAGONISTS

SAARI, W. S., HALCZENKO, W., KING, S. W., HUFF, J. R., GUARE, J. P. JUN., HUNT, C. A., RANDALL, W. C., ANDERSON, P. S., LOTTI, V. J., TAYLOR, D. A., CLINESCHMIDT, B. V.

Journal:

Chemischer Informationsdienst

Year:

1984

File:

PDF, 107 KB

1984

46

Pyridinylpiperazines, a new class of selective .alpha.2-adrenoceptor antagonists

Halczenko, Wasyl, King, Stella W., Huff, Joel R., Guare, James P., Hunt, Cecilia A., Randall, William C., Anderson, Paul S., Lotti, Victor J., Saari, Walfred S.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 790 KB

english, 1983

47

Synthesis and reactions of some dihydro and tetrahydro-4H-imidazo[5,4,1-ij]quinoline derivatives

Walfred S. Saari, Wasyl Halczenko, Mark B. Freedman, Byron H. Arison

Journal:

Journal of Heterocyclic Chemistry

Year:

1982

File:

PDF, 319 KB

1982

48

3-Hydroxy-.alpha.-methyltyrosine progenitors, synthesis and evaluation of some (2-oxo-1,3-dioxol-4-yl)methyl esters

Saari, Walfred S., Halczenko, Wasyl, Cochran, David W., Dobrinska, Michael R., Vincek, William C., Titus, David C., Gaul, S. Lee, Sweet, Charles S.

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 685 KB

english, 1984

49

ChemInform Abstract: Regioselective Generation and Trapping of Mono- and Dianions of 3-Arylsulfonylfurans. Bidentate Carbanion Stabilization via Sulfones.

HARTMAN, G. D., HALCZENKO, W.

Journal:

Year:

1987

File:

PDF, 206 KB

1987

50

ChemInform Abstract: IMINIUM ION MEDIATED CYCLIZATIONS OF 4-ARYL-1,4-DIHYDROPYRIDINES. BRIDGING WITH OLEFINS

HARTMAN, G. D., HALCZENKO, W., PHILLIPS, B. T.

Journal:

Chemischer Informationsdienst

Year:

1985

File:

PDF, 144 KB

1985

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